I edited my last post."When you refer to your old settings are you referring to those from your USB install of Porteus or the prior boot of the Ventoy Porteus system?"
Why? If the changes.dat is an empty file. (You said it's empty) Why should dev be better?On the APPEND line try changing the /mnt/sdc1/ to /dev/sdc1/.
The Link to the Grub2 Plugin: "It should be noted that, when you use this plugin you should be familiar with grub2 and know exactly what you are doing."
I am not familiar with GRUB2 and don't know what I do - to be honest.

And I don't know, why Grub2 should be the problem. The ventoy menu is fine. I select porteus.iso an the Welcome Screen of porteus starts. All good.
Ok. That is elegant.When I boot my ISOs any config changes I need or files that I want I add outside the ISO and to my grub2 menus. And my grub2 menus are manually adjusted outside of the app that created them. On my sda6 drive I have my ISOs and my changes and Module folders, along with a bunch of others,
From where? porteus.cfg is in the iso. ventoy grub2 menu? That lies on a separate partition and i don't see it in Windows.and I refer to them via boot cheatcodes.